Welcome to StructRMDB !

Post-transcriptional RNA modifications play a crucial role in shaping the functional diversity of RNA molecules, and modulate essential RNA functions such as translation, splicing, stability and interaction with proteins, etc., many of which were achieved through its structure changes. To systematically address this challenge, we have developed StructRMDB, a database containing more than 880,000 RNA modification sites that may induce RNA secondary structure changes, covering nine species from more than 80 studies, including three modification types, N6-methyladenosine (m6A), pseudouridine (Ψ), and adenosine-to-inosine editing (A-to-I). State-of-art computational models (RNAstructure and ViennaRNA) were adopted to assess potential RNA secondary structure changes due to the incorporation of RNA modification, and the change was further quantitively measured using four different evaluation metrics, including similarity and secondary-structural motif-comparing score (SMC). Besides, the database also provides various functional annotations, such as, single nucleotide polymorphisms (SNPs), RNA binding protein and microRNAs binding sites for further comparative and functional analysis. StructRMDB offers convenient access to the first comprehensive collection of structure-affecting RNA modification sites together with essential annotations via a user-friendly interface and should make a useful resource to study the structural impact of RNA modification at single nucleotide resolution.